Ponstel is a drug with analgesic, antipyretic and anti-inflammatory effects. Postel is produced in the form of tablets (in blister packs of 10 pcs., 1 or 2 packs in a carton box). One tablet includes an active substance, which is Mefenamic acid - 0.5 g, and auxiliary components, which are octadecanoic acid, potato starch, methylcellulose, croscarmellose sodium, and magnesium stearate.
Ponstel is a derivative of anthranilic acid and belongs to the group of antirheumatic and non-steroidal anti-inflammatory drugs. The drug is able to reduce the intensity of production by the body of specific inflammatory mediators - prostaglandins and serotonin.
Ponstel affects both the central mechanisms of increased pain sensitivity and the processes occurring in the periphery, and it also inhibits the activity of lysosome proteases.
Ponstel helps stabilize cell membranes and protein ultrastructures eliminate puffiness and reduce capillary permeability. The antipyretic effect of the active component of the drug is explained by its ability to act on the thermoregulation center located in the brain and inhibit the production of inflammatory mediators.
Ponstel side effects are gastrointestinal disorders, manifested as dyspepsia, gastrointestinal discomfort, pain in the epigastric region, diarrhea, and an increase in liver enzymes. The drug can lead to the development of gastric ulcers and gastrointestinal bleeding.
The following side effects may also occur during therapy:
• Cardiovascular system:
Increased blood pressure, rhythm disturbances, peripheral edema;
Rarely, congestive heart failure.
• Central nervous system:
Very rarely - irritability, sleep disturbance.
• Urogenital system:
Non-specific inflammation of the kidneys, functional disorders of the kidneys, dysuria, albuminuria, hematuria.