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Loxitane (Generic) is a drug that has a powerful immunosuppressive and cytostatic effect.
The immunosuppressive effect of the drug leads to more significant inhibition of delayed-type hypersensitivity, as well as to the cellular cytotoxicity (in comparison with the production of antibodies).
The active substance inhibits the metabolism of purines, can suppress the synthesis of protein, RNA and DNA, as well as effect cell metabolism, suppress mitosis.
In rheumatoid arthritis or other autoimmune processes, the mechanism of action of azathioprine is unknown, however, presumably, it is due to immunosuppression. As a result of the use of Loxitane (Generic), the need for taking glucocorticoids during combination therapy is reduced.
Loxitane (Generic) has the following pharmacological effects:
Immunosuppressive (after drug withdrawal, clinical effects may persist for a long time);
Antirheumatic (drug transforming the disease): begins to act after 6-8 weeks;
Anti-inflammatory (with systemic lupus erythematosus and intestinal diseases): it takes effect in 4–8 weeks.
Loxitane (Generic) is characterized by a high absorption from the gastrointestinal tract and a low bond to plasma proteins (30%).
Further metabolism occurs in the liver (mainly with the participation of xanthine oxidase) and in erythrocytes, the ratio of which is different in different patients. The liver and kidneys carry out elimination. And from 1 to 2% in the form of unchanged substance. Hemodialysis is partially removed.
According to the instructions, Loxitane (Generic) is used for the following diseases:
Idiopathic thrombocytopenic purpura;
Nonspecific ulcerative colitis;
Chronic hepatitis in the active stage;
Systemic lupus erythematosus;
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.